Description

Haplogroup C4 (mtDNA) is a subclade of haplogroup C distributed primarily in South Siberia, Central Asia, and Mongolia. It is found at moderate frequencies in Altaic, Tuvan, Buryat, and other South Siberian populations, as well as in some Central Asian groups. Unlike C1 which is characteristic of the Americas, C4 is primarily an Asian lineage. It appears to have originated in the South Siberian or Central Asian region and diversified there, representing an important component of the mtDNA diversity of Inner Asia.

Interesting Fact

C4 is frequently found in populations associated with the Altai region — a geographic crossroads that ancient genomics has identified as a key staging area for populations that later expanded into Northeast Asia, Siberia, and the Americas.

Distribution by Ethnicity

Ethnic distributionRegionFrequencySample
TuvansSouth Siberia
12%
n=300
AltaiansSouth Siberia
10%
n=300
BuryatsSouth Siberia
8%
n=400
MongoliansCentral/East Asia
6%
n=600

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References

  1. Derenko et al. (2007) — Phylogeographic analysis of mitochondrial DNA in North Asian populations. American Journal of Human Genetics 81(5), 1025–1041.